Specialties：Internal Medicine-Nephrology,

Clinical Interests：Diabetic kidney disease, Monoclonal Immunoglobulin-related Kidney Diseases

Bio：

2004.7- Present  Division of Nephrology,Guangdong Provincial People’s Hospital, Guangdong Academy of MedicalSciences, Attending doctor(2004.12),Associate Professor(2006.12),Professor (2012.12)

2008.3-2010.8  Division of Nephrology,Baylor College of Medicine，Post Doc

1992.7-1999.9 Division of Nephrology,the First Affiliated Hospital, Wannan Medical College

Resident, Chief resident, Fellow,

Education：

2008.3-2010.8  Division of Nephrology,Baylor College of Medicine

PostDoctory Fellow,Mentor: Dr. Farhad R. Danesh

1999.9-2004.6  Division of Nephrology, the First Affiliated Hospital, Sun Yat-sen University of Medicine Sciences,Ph.D. student,Supervisor: Professor Xueqing Yu

1987.9-1992.6 Wannan Medical College, M. D.student

Awards and Honors：

2018  National 100 Excellent Teachers

2017  Second Prize for Progress in Science and Technology of Guangdong Province

2011  Third Prize for Progress in Science and Technology of Guangdong Province

2007  Third Prize for Progress in Science and Technology of Guangdong Province

Professional memberships：

Editorial BoardMember:  Chinese Journal ofPractical Intermedicine

Chinese Journal of Nephrology (from 2017)

Reviewer:

Peer reviewer of  Kidney International (from 2008),Oncotarget (from 2015),

Scientific Reports (from 2014)

Member:

Vice-Chairman, Guangdong-Hong Kong-Macau Greater Bay Area Medical Association

Member ofInternational Society of Nephrology (from 2016)

Vice Chairman, Guangdong Society ofInternal Medicine(from 2015)

Vice Chairman ofYouth committee, Guangdong Society of Nephrology (from 2011)

Member of American Society of Nephrology (from 2011)

Fellow of American Society of Nephrology (from 2009)

Publications：

1. Zhang Y,Wang W*. Modified Arteriosclerosis Score Predicts the Outcomes of Diabetic Kidney Disease. BMC Nephrol, 2021.(accepted)

2. Wang Y,Wang W*.Development and validation of a simple equation to evaluate dietary protein intake using the blood urea nitrogen/serum creatinine ratio in patients with stage 3 chronic kidney disease. International Urology and Nephrology,2021.(accepted)

3. Li Q,Wen F, Fu L, Xie J, Xie JT, Zuo YY, Jv M, Li S, Wang HZ, Shi W,Wang W*. Diabetic kidney disease benefits from intensive and early diet protein restriction: updated systematic review and meta- analysis. Diabetes Ther. 2021 Jan;12(1):21-36.

4. Liang T, Qi C, Lai Y, Xie J, Wang H, Zhang L, Lin T, Jv M, Li J, Wang Y, Zhang Y, Chen Z, Qiu X, Li R, Li Z, Ye Z, Liu S, Liang X, Shi W, Wang W*.HDAC6-mediated α-tubulin deacetylation suppresses autophagy and enhances motility of podocytes in diabetic nephropathy. J Cell Mol Med. 2020 Oct;24(19):11558-11572.

5. Zhuang X, Cao D, Zeng Y, Yang D, Yao J, Kuang J, Xie J, He M, Cai D, Zhang S, Wang W*, Zhang L. Associations between retinal microvasculature/microstructure and renal function in type 2 diabetes patients with early chronic kidney disease. Diabetes Res Clin Pract. 2020 Aug 19:108373. doi: 10.1016/j. diabres.2020.108373.

6. Wang H, Feng Z, Xie J,Wen F, Fu L, Xie JT, Zuo YY, Jv M, Li S, Wang HZ, Shi W,Wang W*. Podocyte-Specific Knockin of PTEN Protects Kidney from Hyperglycemia. Am J Physiol Renal Physiol 2018,313(2):F339-F350.

7. Li SH, Xie JT, Long HB, Zhang J, Zhou WD, Niu HX, Tang X, Feng ZL, Ye ZM, Zuo YY, Fu L, Wen F, Wang LP, Wang WJ *, Shi W. Time-averaged serum potassium levels and its fluctuation associate with 5-year survival of peritoneal dialysis patients: two-center based study. Sci Rep.2015, 28(5):15743

8. Xie J, Wang H, Li S, Zuo Y, Wang Y, Zhang Y, Liang T, Li J, Wang L, Feng Z, Ye Z, Liang X, Shi W,Wang W*.Low-volume Tidal Peritoneal Dialysis is A Preferable Mode in Patients Initiating Urgent-start Automated Peritoneal Dialysis: A Randomized, Open-label, Prospective Control Study. Ther Apher Dial. 2019 Oct;23(5):409-417.

9. Wang W, Wang Y, Long J, Wang J, Haudek SB, Overbeek P, Chang BH, Schumacker PT, Danesh FR. Mitochondrial Fission Triggered by Hyperglycemia Is Mediated by ROCK1 Activation in Podocytes and Endothelial Cells. Cell Metab 2012,15(2):186-200.

10. Wang W, He B, Shi W, Liang X, Ma J, Shan Z, Hu Z, Danesh F R. Deletion of scavenge receptor A protects mice from progressive nephropathy independent of lipid control during diet-induced hyperlipidemia. Kidney Int. 2012, 81(10):1002-1014.

11. Dou C, Zhang H, Ke G, Zhang L, Lian Z, Chen X, Zhao X, Chen Y, Li R, Ma J, Li Z, Lin T, Wang W,Ye ZM, Liang X, Shi W, Zhang B, Liu S. The Krüppel-like factor 15-NFATc1 axis ameliorates podocyte injury: a novel rationale for using glucocorticoids in proteinuria diseases.Clin Sci (Lond). 2020 Jun 26;134(12):1305-1318.

12. Xie Z, Li Z, Dong W, Chen Y, Li R, Wu Y, Lin T, Tao Y, Liang H, Wang W, Liu S, Ye Z, Shi W, Liang X. Metabolic syndrome and concomitant diabetes mellitus are associated with higher risk of cardiovascular comorbidity in patients with primary glomerular diseases: A retrospective observational study. Clin Cardiol. 2020;1–8.

13. Xie Z, Dong W, Li Z, Chen Y, Song L, Li R, Wu Y, Fu L, Liang H, Tao Y, Xie J,Wang W, Liu S, Ye Z, Shi W, Liang X. Clinical value of renal phospholipase A2 receptor deposit in the prognosis evaluation and treatment options of idiopathic membranous nephropathy: A retrospective cohort study. Nephrology(Carlton). 2020,25(3):219-229

14. Zhang H, Liang S, Du Y, Li R, He C,Wang W,Liu S, Ye Z, Liang X, Shi W, Zhang B. Inducible ATF3-NFAT axis aggravates podocyte injury.J Mol Med. 2018, 96(1):53-64.

15. Zhang L, Zhang Q, Liu S, Chen Y, Li R, Lin T, Yu C, Zhang H, Huang Z, Zhao X, Tan X, Li Z, Ye Z, Ma J, Zhang B, Wang W, Shi W, Liang X.DNA methyltransferase 1 may be a therapy target for attenuating diabetic nephropathy and podocyte injury. Kidney Int. 2017, 92(1):140-153.

16. Huang Z, Zhang L, Chen Y, Zhang H, Yu C, Zhou F, Zhang Z, Jiang L, Li R, Ma J, Li Z, Lai Y, Lin T, Zhao X, Zhang Q, Zhang B, Ye Z, Liu S,Wang W, Liang X, Liao R, Shi W. RhoA deficiency disrupts podocyte cytoskeleton and induces podocyte apoptosis by inhibiting YAP/dendrin signal. BMC Nephrol. 2016, 17(1):66.

17. Huang Z, Zhang L, Chen Y, Zhang H, Zhang Q, Li R, Ma J, Li Z, Yu C, Lai Y, Lin T, Zhao X, Zhang B, Ye Z, Liu S,Wang W, Liang X, Liao R, Shi W. Cdc42 deficiency induces podocyte apoptosis through inhibiting Nwasp/stress fibers/YAP pathway. Cell Death & Disease, 2016, 17;7:e2142.

18. Long J, Wang Y, Wang W, Chang BH, Danesh FR. MicroRNA-29c is a signature MicroRNA under high glucose conditions which targets sprouty homolog 1, and its in vivo knockdown prevents progression of diabetic nephropathy. J Biol Chem. 2011, 286(13):11837-11848.

19. Long J, Wang Y, Wang W, Chang BH, Danesh FR. Identification of MicroRNA-93 as a Novel Regulator of Vascular Endothelial Growth Factor in Hyperglycemic Conditions. J Bio Chem. 2010, 285(30):23457-23465.

20. Xiao H, Shi W, Liu S, Wang W, Zhang B, Zhang Y, Xu L, Liang X, Liang Y. 1,25- Dihydroxyvitamin D(3) Prevents Puromycin Aminonucleoside-Induced Apoptosis of Glomerular Podocytes by Activating the Phosphatidylinositol 3-Kinase/Akt- Signaling Pathway. Am J Nephrol. 2009, 30(1):34-43.