Title: Vice President of Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences)；Director of Division of Emergency
Specialties: Over the past decades, he has been engaged in the treatment of cardiovascular critical disease, and has made in-depth research on the pathogenesis of aortic dissection, the therapeutic effect of vascular stem cells, and the treatment of brain injury after cardiac arrest.
Clinical Interests: cardiovascular critical disease; the treatment of brain injury after cardiac arrest

Education:
1991.09-1996.07     Jining Medical Univercity     Clinical Medicine         B.A.
2000.09-2003.07     Sun Yat-sen University        Emergency Medicine     M.A.
2005.09-2008.07     Sun Yat-sen University        Emergency Medicine     M.D.

Awards and Honors:

[1]Young and middle-aged experts with outstanding contributions to national health in 2017

[2]Medical Leading Talents/ Outstanding Young Medical Talents of Guangdong Province in 2018

[3]Third-class Merit for “fighting SARS” by Guangdong provincial Party committee and provincial government in 2003

Professional memberships:

[1]Standing Committee Member of Guangdong Medicial Association Emergency Branch

[2]Vice chairman of Southern Medical Rescue Training Center, Health Emergency Committee, Chinese Research Hospital Association

[3]Vice chairman of Guangdong Provicial CPR Training Committee, CPR Committee of China Research Hospital Association

[4] Member of emergency branch of Chinese Medical Association

[5] Vice chairman of quality control group of emergency branch of Chinese Medical Association

[6] Chairman of Tibet Aid Committee of Guangdong Medical Association

Publications:
（1）Yang KH#, Ren J#, Li X#, Wang Z, Cui SM, Sang WT, Xu TH, Zhang J, Yu JQ, Liu ZP, Shang HX, Pang JJ, Huang XR, Chen YG*, Xu F*. Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype. European Heart Journal. 2020 ;41(26):2442-2453. DOI:: 10.1093/eurheartj/ehaa352.(共同第一作者，SCI收录，IF:22.673)
（2）Hong YM, He HW, Jiang GJ, Zhang H, Tao WY, Ding Y, Yuan DS, Liu J, Fan HM, Lin F, Liang XT*, Li X*, Zhang YL*. MiR-155-5p Inhibition Rejuvenates Aged Mesenchymal Stem Cells and Enhances Cardioprotection following Infarction. Aging Cell, 2020. e13128. DOI: 10.1111/acel.13128. (共同通讯作者，SCI 收录，IF:7.346）
（3）Zhou XK, Hong YM, Zhang H, Li X*. Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges. Frontiers in Cell and Developmental Biology. 2020; 8:364. DOI: 10.3389/fcell.2020.00364. eCollection 2020. (通讯作者，SCI收录，IF: 5.201)
（4）You W, Hong YM, He HW, Huang XR, Tao WY, Liang XT, Zhang YL*, Li X*. TGF-β Mediates Aortic Smooth Muscle Cell Senescence in Marfan Syndrome. Aging-US, 2019;11(11):3574-3584. (通讯作者，SCI 收录，IF:5.515）
（5）Zhang YL#, Zhu WW#, He HW#, Fan BH, Deng R, Hong YM, Liang XT, Zhao HY, Li X*, Zhang FX*. Macrophage Migration Inhibitory Factor Rejuvenates Aged Human Mesenchymal Stem Cells and Improves Myocardial Repair. Aging-US, 2019, 11(24): 12641-12660. (共同通讯作者，SCI 收录，IF:5.515）
（6）Li X#, Hong YM#, He HW, Jiang GJ, You W, Liang XT, Fu QL, Han S, Lian QZ, Zhang YL*. FGF21 Mediates Mesenchymal Stem Cell Senescence via Regulation of Mitochondrial Dynamics. Oxidative Medicine and Cellular Longevity. 2019;2019:4915149. (第一作者，SCI 收录，IF:4.868）
（7） Huang XR, Zhang H, Liang XT, Hong YM, Mao MM, Han Q, He HW, Tao WY, Jiang GJ, Zhang YL*, Li X*. Adipose-Derived Mesenchymal Stem Cells Isolated from Patients with Abdominal Aortic Aneurysm Exhibit Senescence Phenomena. Oxidative Medicine and Cellular Longevity. 2019, 2019: 1305049. (通讯作者，SCI 收录，IF:4.868）
（8）He HW, Yu BQ, Liu ZP, Ye G, You W, Hong YM, Lian QZ, Zhang YL*, Li X*. Vascular Progenitor Cell Senescence in Patients with Marfan Syndrome. Journal of Cellular and Molecular Medicine. 2019; 23(6):4139-4152. (通讯作者，SCI 收录，IF:4.658）
（9） Liu XL#, Li X#, Zhu WW#, Zhang YL, Hong YM, Liang XT, Fan BH, Zhao HY, He HW, Zhang FX*. Exosomes from mesenchymal stem cells overexpressing MIF enhance myocardial repair. Journal of cellular physiology 2020. DOI: 10.1002/jcp.29456. (共同第一作者,SCI 收录，IF:4.522)
（10） Fan XL#, Zeng QX#, Li X#, Li CL, Xu ZB, Deng XQ, Shi JB, Chen D, Zheng SG*, Fu QL*. Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Activate Quiescent T Cells and Elevate Regulatory T Cell Response via NF-κB in Allergic Rhinitis Patients. Stem Cell Research & Therapy , 2018, 9(1): 170-185. (共同第一作者, SCI 收录，IF:4.627)
（11） Sun YQ#, Zhang Y#, Li X#, Deng MX, Gao WX, Yao Y, Chiu SM, Liang X, Gao F, Chan CW, Tse HF, Shi J, Fu QL*, Lian QZ*. Insensitivity of Human iPS Cells-Derived Mesenchymal Stem Cells to Interferon-gamma-induced HLA Expression Potentiates Repair Efficiency of Hind Limb Ischemia in Immune Humanized NOD Scid Gamma Mice. Stem Cells. 2015;33(12): 34523467 (共同第一作者, SCI收录，IF:5.614)
（12） Hu CL#, Liu R#, Liao XX, Wei HY, Li X*, Zhan H, Jing XL, Xiong Y, Huang GQ, Wu GF. Early enhanced external counter pulsation improves neurological recovery after the return of spontaneous circulation in a mongrel dog cardiac arrest model. Critical Care Medicine, 2013, 41(6): 62-73. (通讯作者，SCI 收录，IF:6.971)
（13）Liu R#, Li X#, Hu CL, Jiang L, Dai G, Wu GF, Huang GQ, Wei HY, Liao XX*. The changes of brain water diffusion and blood flow on diffusion-weighted and perfusion-weighted imaging in a canine model of cardiac arrest. Resuscitation, 2012, 83(5):645-651. (共同第一作者，SCI 收录，IF: 4.572)
（14）Lin JY#, Liao XX#, Li H, Wei HY, Liu R, Hu CL, Huang GQ, Dai G, Li X*. Model of cardiac arrest in rats by transcutaneous electrical epicardium stimulation. Resuscitation. 2010, 81(9):1197-1204. (通讯作者, SCI收录, IF: 4.572)
（15）Jiang WQ#, Li XS#, Ding HG#, Wang KR, Liu XY, Wang QS, Li Y, Zhou MH, Chen SL, Zhong WH, Li X*, Zeng HK*.PD-1 in Tregs predicts the survival in sepsis patients using sepsis-3 criteria: A prospective, two-stage study. International Immunopharmacology. 2020，89(Pt A):107175. (共同通讯作者，SCI 收录，IF:3.943）
（16）Chen SL#, Feng HY#, Xu H#, Huang SS, Sun JF, Zhou L, He JL, Song WL, Wang RJ, Li X*, Fang M*. Patterns of Deterioration in Moderate Patients With COVID-19 From Jan 2020 to Mar 2020: A Multi-Center, Retrospective Cohort Study in China. Frontiers in Medicine. 2020, 7:567296. (共同通讯作者，SCI 收录，IF:3.421）
(17) Shi LL#, Han Q#, Hong YM, Li WF, Gong GC, Cui JY, Mao MM, Liang XT, Hu B, Li X*, Luo Q*, Zhang YL*. Inhibition of miR-199a-5p rejuvenates aged mesenchymal stem cells derived from patients with idiopathic pulmonary fibrosis and improves their therapeutic efficacy in experimental pulmonary fibrosis. Stem Cell Research ＆ Therapy.2021,12:147. (共同通讯作者，SCI 收录，IF:5.081）
(18) Li WF#, Shi LL#, Hu B, Hong YM, Zhang H, Li X*, Zhang YL*. Mesenchymal Stem Cell-Based Therapy for Stroke: Current Understanding and Challenges. Frontiers in Cellular Neuroscience. 2021,15:628940. (共同通讯作者，SCI 收录，IF:3.943）
(19) Tao WY, Hong YM, He HW, Han Q, Mao MM, Hu B, Zhang H, Huang XR, You W, Liang XT, Zhang YL*, Li X*. MicroRNA-199a-5p aggravates angiotensin II-induced vascular smooth muscle cell senescence by targeting Sirtuin-1 in abdominal aortic aneurysm. Journal of Cellular and Molecular Medicine. (共同通讯作者，SCI 收录，IF:4.658）