Recently, a national multicenter, randomized controlled study (investigator-initiated trial, IIT) led by Prof. Chen Jiyan and Prof. Tan Ning from the Department of Cardiology of our hospital – Simplified Rapid Hydration Prevents Contrast-Associated Acute Kidney Injury Among CKD Sufferers Undergoing Coronary Angiography – TIME Study (simplified new hydration therapy for chronic kidney disease), was published in JACC: Cardiovascular Interventions (CAS Small Q1, IF (2022)=11.3, the top-ranking professional journal in the field of cardiovascular interventions). Our hospital is the first and corresponding authors of this research achievement.

According to Director Liu Yong, the main researcher of the project, sufferers with chronic kidney disease (CKD) undergoing coronary intervention surgery are prone to contrast-associated acute kidney injury (CA-AKI). The results of this study show that for CKD sufferers undergoing coronary intervention surgery, the effectiveness and safety of the CA-AKI prevention scheme of simplified rapid hydration are not inferior to those of the long-term hydration strategy recommended in the prevailing European and American guidelines for coronary intervention surgery; compared to the hydration methods recommended in the guidelines, simplified new hydration scheme established in this study can effectively shorten the venous hydration time by nearly four times, thereby shortening hospital stays, and improving medical efficiency and sufferer experiences.

Prof. Hitinder S. Gurm, the head of the Department of Cardiology at VA Ann Arbor Health Care System, University of Michigan in the U.S., made a concurrent review: The simplified rapid hydration scheme proposed by the TIME study is an important supplement to the long-term hydration scheme recommended by the prevailing guidelines, and it may be time to modify the guidelines for the hydration strategy for coronary intervention surgery.

Department of Cardiology

Updated: July 19, 2023